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Peptides usually have unstable structures. To create SP9, the group utilised a method referred to as hydrocarbon stapling to freeze it inside a shape that blocks Syt2 from interacting With all the cell membrane proteins.
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That has a Specific carrier section sp9 included to its sequence, the peptide efficiently entered the cells. If the cells were stimulated to secrete mucin, SP9 minimized secretion by eighty three%.
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